Review Article
Aminonaphthoquinone: A Versatile Synthon for the Synthesis of Naphthoquinone-fused N-heterocycles via Multicomponent Reactions (MCRs)
Issue:
Volume 10, Issue 2, December 2025
Pages:
26-40
Received:
25 May 2025
Accepted:
11 June 2025
Published:
28 August 2025
Abstract: The naphthoquinone-fused N-heterocycles are found in natural products and are important candidates in medicinal chemistry. The 1, 3-C, N-binucleophilic property of the 2-aminonaphthoquinone provides access for the synthesis of naphthoquinone-fused N-heterocycles. In recent years this property of 2-aminonaphthoquinone has been acknowledged greatly by the synthetic community for construction of variably dubstituted naphthoquinone-fused N-heterocycles. This review summarizes the important findings in this area during 2019-2024. Also the review highlights the gap and future perspective of the approach.
Abstract: The naphthoquinone-fused N-heterocycles are found in natural products and are important candidates in medicinal chemistry. The 1, 3-C, N-binucleophilic property of the 2-aminonaphthoquinone provides access for the synthesis of naphthoquinone-fused N-heterocycles. In recent years this property of 2-aminonaphthoquinone has been acknowledged greatly b...
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,
Bishwajit Das
